It was only when I got home that I realised he’d made a mis-steak.Ĩ. I asked my butcher to give me some t-bones, but instead he gave me sirloins. The skeleton was so stupid, he was a total numskull.ħ. Try as she might, the skeleton just couldn’t manage to drag herself out of bed. I knew the skull wasn’t going to win the argument. You can always tell when a spine finds your bone puns funny. Therefore, the current review hopes to provide valuable information around the application of mussel-inspired compounds in dentistry with their pros and cons discussed.īiomaterial Catechol Dopa Mussel Wet adhesion.Ĭopyright © 2021 The Academy of Dental Materials. Despite the emergence of several mussel-inspired compounds in recent years, a comprehensive and timely review of their applications in dentistry is lacking. The mussel's wet adhesion ability has attracted much research interest in the dental field because of its properties of moisture-resistant adhesion and surface coating. However, two practical problems remain to be comprehensively addressed, namely the protection of catechol groups from oxidation, and the feasibility for clinical application. Mussel-inspired compounds have achieved relatively acceptable performances in various dental fields, including surface coating, metal ions chelation, dentin bonding and mucosal adhesion. Therefore, this review discusses the mussel adhesion chemistry and its related application in dentistry. These challenges have influenced an increasing number of studies that are exploring the translation of mussel-inspired adhesion to clinical applications. Similar to mussels in the marine environment, dental materials in the oral environment have to endure long-term water hydrolysis, mechanical stress and other chemical challenges. Inspired by the wet adhesion property of 3,4-dihydroxyphenol-l-alanine (Dopa) in mussel plaques, various chemical compounds have been synthesized to mimic the mussel as an adhesion model for medical applications. To give a current review of the mechanism of mussel adhesion, the application of mussel-inspired compounds in dentistry and the challenges associated with clinical application.
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